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STRUCTURAL ANALYSIS OF SUBSTRATE AND EFFECTOR BINDING IN MYCOBACTERIUM TUBERCULOSIS D-3-PHOSPHOGLYCERATE DEHYDROGENASE

The crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase has been solved with bound effector, L-serine, and substrate, hydroxypyruvic acid phosphate, at resolutions of 2.7 Å and 2.4 Å, respectively. The structures display the same extreme asymmetry of the subunits as se...

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Detalhes bibliográficos
Main Authors: Dey, Sanghamitra, Burton, Rodney L., Grant, Gregory A., Sacchettini, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2551328/
https://ncbi.nlm.nih.gov/pubmed/18627175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800212b
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