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Binding of Insulin-like Growth Factor (IGF)–Binding Protein-5 to Smooth-Muscle Cell Extracellular Matrix Is a Major Determinant of the Cellular Response to IGF-I

Insulin-like growth factor–binding protein-5 (IGFBP-5) has been shown to bind to fibroblast extracellular matrix (ECM). Extracellular matrix binding of IGFBP-5 leads to a decrease in its affinity for insulin-like growth factor-I (IGF-I), which allows IGF-I to better equilibrate with IGF receptors. W...

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Autori principali: Parker, Alex, Rees, Catherine, Clarke, Jane, Busby, Walker H., Clemmons, David R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC25505/
https://ncbi.nlm.nih.gov/pubmed/9725901
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