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Unfolding and Melting of DNA (RNA) Hairpins: The Concept of Structure-Specific 2D Dynamic Landscapes

A 2D free energy landscape model is presented to describe the (un)folding transition of DNA/RNA hairpins, together with molecular dynamics simulations and experimental findings. The dependence of the (un)folding transition on the stem sequence and the loop length is shown in the enthalpic and entrop...

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Autors principals: Lin, Milo M., Meinhold, Lars, Shorokhov, Dmitry, Zewail, Ahmed H.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2548322/
https://ncbi.nlm.nih.gov/pubmed/18633543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b804675c
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