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Synthesis and Characterization of Insulin-Transferrin Conjugates
Receptor- mediated endocytosis can be exploited for improving the transcellular delivery of therapeutic proteins. Insulin conjugated to transferrin by forming disulfide bonds has been shown to improve insulin oral bioavailability in diabetic rats. We are developing a combination strategy involving c...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2547411/ https://ncbi.nlm.nih.gov/pubmed/17105214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc050344k |
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