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Synthesis and Characterization of Insulin-Transferrin Conjugates
Receptor- mediated endocytosis can be exploited for improving the transcellular delivery of therapeutic proteins. Insulin conjugated to transferrin by forming disulfide bonds has been shown to improve insulin oral bioavailability in diabetic rats. We are developing a combination strategy involving c...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2547411/ https://ncbi.nlm.nih.gov/pubmed/17105214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc050344k |
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