Llama-Derived Single-Chain Antibody Fragments Directed to Rotavirus VP6 Protein Possess Broad Neutralizing Activity In Vitro and Confer Protection against Diarrhea in Mice

Group A rotavirus is one of the most common causes of severe diarrhea in human infants and newborn animals. Rotavirus virions are triple-layered particles. The outer capsid proteins VP4 and VP7 are highly variable and represent the major neutralizing antigens. The inner capsid protein VP6 is conserv...

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Autors principals: Garaicoechea, Lorena, Olichon, Aurelien, Marcoppido, Gisela, Wigdorovitz, Andrés, Mozgovoj, Marina, Saif, Linda, Surrey, Thomas, Parreño, Viviana
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546978/
https://ncbi.nlm.nih.gov/pubmed/18632867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00436-08
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