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Identification of an Arginine-Rich Motif in Human Papillomavirus Type 1 E1^E4 Protein Necessary for E4-Mediated Inhibition of Cellular DNA Synthesis In Vitro and in Cells

Productive infections by human papillomaviruses (HPVs) are restricted to nondividing, differentiated keratinocytes. HPV early proteins E6 and E7 deregulate cell cycle progression and activate the host cell DNA replication machinery in these cells, changes essential for virus synthesis. Productive vi...

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Main Authors: Roberts, Sally, Kingsbury, Sarah R., Stoeber, Kai, Knight, Gillian L., Gallimore, Phillip H., Williams, Gareth H.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546886/
https://ncbi.nlm.nih.gov/pubmed/18632869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01080-08
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