Identification of an Arginine-Rich Motif in Human Papillomavirus Type 1 E1^E4 Protein Necessary for E4-Mediated Inhibition of Cellular DNA Synthesis In Vitro and in Cells

Productive infections by human papillomaviruses (HPVs) are restricted to nondividing, differentiated keratinocytes. HPV early proteins E6 and E7 deregulate cell cycle progression and activate the host cell DNA replication machinery in these cells, changes essential for virus synthesis. Productive vi...

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Bibliographic Details
Main Authors: Roberts, Sally, Kingsbury, Sarah R., Stoeber, Kai, Knight, Gillian L., Gallimore, Phillip H., Williams, Gareth H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546886/
https://ncbi.nlm.nih.gov/pubmed/18632869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01080-08
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