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Establishing the Absolute Configuration of the Asbestinins: Enantioselective Total Synthesis of 11-Acetoxy-4-deoxyasbestinin D

A highly stereoselective synthesis of 11-acetoxy-4-deoxyasbestinin D (1) has been completed in 26 linear steps. The synthesis hinges on a selective glycolate aldol addition to establish the C-2 stereocenter, a ring-closing metathesis reaction to complete the oxonene, and an intramolecular Diels-Alde...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Crimmins, Michael T., Ellis, J. Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2005
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546569/
https://ncbi.nlm.nih.gov/pubmed/16332064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja056921x
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