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Natural variation of HIV-1 group M integrase: Implications for a new class of antiretroviral inhibitors

HIV-1 integrase is the third enzymatic target of antiretroviral (ARV) therapy. However, few data have been published on the distribution of naturally occurring amino acid variation in this enzyme. We therefore characterized the distribution of integrase variants among more than 1,800 published group...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Rhee, Soo-Yon, Liu, Tommy F, Kiuchi, Mark, Zioni, Rafael, Gifford, Robert J, Holmes, Susan P, Shafer, Robert W
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546438/
https://ncbi.nlm.nih.gov/pubmed/18687142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-5-74
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