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HPMA COPOLYMER-BOUND DOXORUBICIN INDUCES APOPTOSIS IN OVARIAN CARCINOMA CELLS BY THE DISRUPTION OF MITOCHONDRIAL FUNCTION
N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound doxorubicin has showed greater potency than free doxorubicin the treatment ovarian cancer in vivo and in vitro. The promising activity of the conjugate demonstrated in clinical trials has generated considerable interest in understanding the me...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2544630/ https://ncbi.nlm.nih.gov/pubmed/16749867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp050065e |
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