Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors

Endocannabinoids and CB1 receptors have been implicated in endotoxin (LPS)-induced hypotension: LPS stimulates the synthesis of anandamide in macrophages, and the CB1 antagonist SR-141716 inhibits the hypotension induced by treatment of rats with LPS or LPS-treated macrophages. Recent evidence indic...

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Hlavní autoři: Bátkai, Sándor, Pacher, Pál, Járai, Zoltán, Wagner, Jens A., Kunos, George
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2543126/
https://ncbi.nlm.nih.gov/pubmed/15059774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00184.2004
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