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Laminin-induced activation of Rac1 and JNKp46 is initiated by Src family kinases and mimics the effects of skeletal muscle contraction

Laminin-binding to dystroglycan in the dystrophin glycoprotein complex causes signaling through dystroglycan-syntrophin-grb2-SOS1-Rac1-PAK1-JNK. Laminin-binding also causes syntrophin tyrosine phosphorylation to initiate signaling. The kinase responsible was investigated here. PP2 and SU6656, specif...

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Detalhes bibliográficos
Main Authors: Zhou, YanWen, Jiang, Daifeng, Thomason, Donald B., Jarrett, Harry W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542880/
https://ncbi.nlm.nih.gov/pubmed/18044967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701384k
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