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Isolevuglandin-modified proteins, including elevated levels of inactive calpain-1, accumulate in glaucomatous trabecular meshwork
We report that protein adducts of iso[4]levuglandin E(2) (iso[4]LGE(2)), a highly reactive product of free radical-induced lipid oxidation, accumulate in human glaucomatous trabecular meshwork (TM) but not in controls. Reactive oxygen species play a pathogenic role in primary open angle glaucoma by...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2542878/ https://ncbi.nlm.nih.gov/pubmed/18085799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701517m |
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