A vaccine strategy against AIDS: An HIV gp41 peptide immunization prevents NKp44L expression and CD4(+) T cell depletion in SHIV-infected macaques

We previously showed that a gp41 peptide (3S) induces expression of a natural killer (NK) ligand (NKp44L) on CD4(+) T cells during HIV-1 infection and that those cells are highly sensitive to NK lysis. In HIV-infected patients, anti-3S antibodies are associated with the maintenance of CD4(+) T cell...

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Bibliographic Details
Main Authors: Vieillard, Vincent, Le Grand, Roger, Dausset, Jean, Debré, Patrice
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542869/
https://ncbi.nlm.nih.gov/pubmed/18234855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711629105
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