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Tracing the molecular pathogenesis of antiphospholipid syndrome
Fetal loss induced by antiphospholipid antibodies (aPLs) in mice is a complement-driven inflammatory condition. Engagement of the complement receptor C5aR on neutrophils induces expression of the principal initiator of the blood clotting mechanism, tissue factor (TF), and blocking this downstream ev...
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2008
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2542859/ https://ncbi.nlm.nih.gov/pubmed/18802489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37243 |
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