The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate

BACKGROUND: Secreted frizzled related proteins (SFRPs) are multifunctional modulators of Wnt and BMP (Bone Morphogenetic Protein) signalling necessary for the development of most organs and the homeostasis of different adult tissues. SFRPs fold in two independent domains: the cysteine rich domain (S...

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Bibliographic Details
Main Authors: Lopez-Rios, Javier, Esteve, Pilar, Ruiz, Jose Maria, Bovolenta, Paola
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542364/
https://ncbi.nlm.nih.gov/pubmed/18715500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1749-8104-3-19
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