Identification of attenuating mutations on the reovirus type 3 S1 double-stranded RNA segment with a rapid sequencing technique.

Reovirus type 3 variants with mutations in the major neutralization domain of the sigma 1 protein have attenuated neurovirulence and restricted neurotropism. We devised a variation of the rapid RNA sequencing technique to facilitate the analysis of double-stranded RNA. We sequenced the S1 double-str...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Bassel-Duby, R, Spriggs, D R, Tyler, K L, Fields, B N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1986
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC253902/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3528529/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.60.1.64-67.1986
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