Cytoplasmic BK(Ca) channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons

High single-channel conductance K(+) channels, which respond jointly to membrane depolarization and micromolar concentrations of intracellular Ca(2+) ions, arise from extensive cell-specific alternative splicing of pore-forming α-subunit mRNAs. Here, we report the discovery of an endogenous BK(Ca) c...

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Detalles Bibliográficos
Autores principales: Bell, Thomas J., Miyashiro, Kevin Y., Sul, Jai-Yoon, McCullough, Ronald, Buckley, Peter T., Jochems, Jeanine, Meaney, David F., Haydon, Phil, Cantor, Charles, Parsons, Thomas D., Eberwine, James
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2008
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538856/
https://ncbi.nlm.nih.gov/pubmed/18250327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711796105
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