Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization

The childhood epilepsy syndrome of benign familial neonatal convulsions (BFNC) exhibits the remarkable feature of clinical remission within a few weeks of onset and a favourable prognosis, sparing cognitive abilities despite persistent expression of the mutant KCNQ2 or KCNQ3 potassium channels throu...

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Hlavní autoři: Singh, Nanda A, Otto, James F, Jill Dahle, E, Pappas, Chris, Leslie, Jonathan D, Vilaythong, Alex, Noebels, Jeffrey L, Steve White, H, Wilcox, Karen S, Leppert, Mark F
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2008
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538806/
https://ncbi.nlm.nih.gov/pubmed/18483067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.154971
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