Prediction of clinical response based on pharmacokinetic/pharmacodynamic models of 5-hydroxytryptamine reuptake inhibitors in mice

BACKGROUND AND PURPOSE: Bridging the gap between preclinical research and clinical trials is vital for drug development. Predicting clinically relevant steady-state drug concentrations (Css) in serum from preclinical animal models may facilitate this transition. Here we used a pharmacokinetic/pharma...

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Detalhes bibliográficos
Main Authors: Kreilgaard, M, Smith, D G, Brennum, L T, Sánchez, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538695/
https://ncbi.nlm.nih.gov/pubmed/18552871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.243
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