Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activation

Matrix metalloproteinase (MMP) plays a crucial role in periodontal disease and is up-regulated by oral Gram-negative, pathogen-derived LPS. In this study, we reported that simvastatin, a 3-hydroxyl-3-methylglutaryl-CoA reductase inhibitor, effectively inhibited LPS-stimulated MMP-1 as well as MMP-8...

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Bibliographic Details
Main Authors: Sundararaj, Kamala P., Samuvel, Devadoss J., Li, Yanchun, Nareika, Alena, Slate, Elizabeth H., Sanders, John J., Lopes-Virella, Maria F., Huang, Yan
Format: Artigo
Language:Inglês
Published: The Society for Leukocyte Biology 2008
Subjects:
Receptors, Signal Transduction, and Genes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538599/
https://ncbi.nlm.nih.gov/pubmed/18625914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0108064
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