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Protein Docking by the Underestimation of Free Energy Funnels in the Space of Encounter Complexes

Similarly to protein folding, the association of two proteins is driven by a free energy funnel, determined by favorable interactions in some neighborhood of the native state. We describe a docking method based on stochastic global minimization of funnel-shaped energy functions in the space of rigid...

詳細記述

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書誌詳細
主要な著者: Shen, Yang, Paschalidis, Ioannis Ch., Vakili, Pirooz, Vajda, Sandor
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538569/
https://ncbi.nlm.nih.gov/pubmed/18846200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000191
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