HIV-1 with Multiple CCR5/CXCR4 Chimeric Receptor Use Is Predictive of Immunological Failure in Infected Children

BACKGROUND: HIV-1 R5 viruses are characterized by a large phenotypic variation, that is reflected by the mode of coreceptor use. The ability of R5 HIV-1 to infect target cells expressing chimeric receptors between CCR5 and CXCR4 (R5(broad) viruses), was shown to correlate with disease stage in HIV-1...

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Main Authors: Cavarelli, Mariangela, Karlsson, Ingrid, Zanchetta, Marisa, Antonsson, Liselotte, Plebani, Anna, Giaquinto, Carlo, Fenyö, Eva Maria, De Rossi, Anita, Scarlatti, Gabriella
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538568/
https://ncbi.nlm.nih.gov/pubmed/18820725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003292
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