Substituents on Quinone Methides Strongly Modulate Formation and Stability of Their Nucleophilic Adducts

Electronic perturbation of quinone methides (QM) greatly influences their stability and in turn alters the kinetics and product profile of QM reaction with deoxynucleosides. Consistent with the electron deficient nature of this reactive intermediate, electron-donating substituents are stabilizing an...

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Main Authors: Weinert, Emily E., Dondi, Ruggero, Colloredo-Melz, Stefano, Frankenfield, Kristen N., Mitchell, Charles H., Freccero, Mauro, Rokita, Steven E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2006
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538442/
https://ncbi.nlm.nih.gov/pubmed/16953635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja062948k
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