Pharmacology of Novel Heteroaromatic Polycycle Antibacterials

Heteroaromatic polycycle (HARP) compounds are a novel class of small (M(w), 600 to 650) DNA-binding antibacterials. HARP compounds exhibit a novel mechanism of action by preferentially binding to AT-rich sites commonly found in bacterial promoters and replication origins. Noncovalent binding in the...

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Autores principales: Gross, M., Bürli, R., Jones, P., Garcia, M., Batiste, B., Kaizerman, J., Moser, H., Jiang, V., Hoch, U., Duan, J.-X., Tanaka, R., Johnson, K. W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC253762/
https://ncbi.nlm.nih.gov/pubmed/14576101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.11.3448-3457.2003
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