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Enhanced activation of a “nutrient-sensing” pathway with age contributes to insulin resistance
Calorie restriction improves life span whereas nutrient excess leads to obesity and unfavorable metabolic consequences, supporting the role for a cellular “nutrient sensor” in aging. Hexosamine biosynthetic pathway (HBP) is a candidate nutrient-sensing pathway. We hypothesized that altered nutrient...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Federation of American Societies for Experimental Biology
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2537426/ https://ncbi.nlm.nih.gov/pubmed/18566293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-109041 |
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