Enhanced activation of a “nutrient-sensing” pathway with age contributes to insulin resistance

Calorie restriction improves life span whereas nutrient excess leads to obesity and unfavorable metabolic consequences, supporting the role for a cellular “nutrient sensor” in aging. Hexosamine biosynthetic pathway (HBP) is a candidate nutrient-sensing pathway. We hypothesized that altered nutrient...

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Autors principals: Einstein, Francine H., Fishman, Sigal, Bauman, Jeffery, Thompson, Reid F., Huffman, Derek M., Atzmon, Gil, Barzilai, Nir, Muzumdar, Radhika H.
Format: Artigo
Idioma:Inglês
Publicat: The Federation of American Societies for Experimental Biology 2008
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2537426/
https://ncbi.nlm.nih.gov/pubmed/18566293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-109041
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