Poliovirus mutant that contains a cold-sensitive defect in viral RNA synthesis.
By manipulating an infectious cDNA clone of poliovirus, we have introduced a single-codon insertion into the 3A region of the viral genome which has been proposed to encode a functional precursor of the virion-linked protein VPg. The resulting mutant was cold sensitive in monkey kidney cells. Viral...
Guardat en:
| Publicat a: | J Virol |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1988
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC253730/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2839711/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.62.8.2922-2928.1988 |
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