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Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the MGluR5 antagonist MPEP: Comparison with dizocilpine

RATIONALE: The mGluR5 antagonist MPEP has effects that suggest potential as a pharmacotherapy for cocaine addiction. MPEP can attenuate self-administration of cocaine in animals; however, studies usually involved only acute treatment with MPEP and a single dose of self-administered cocaine. Cocaine...

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Main Authors: Platt, Donna M., Rowlett, James K., Spealman, Roger D.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536745/
https://ncbi.nlm.nih.gov/pubmed/18509621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-008-1191-y
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