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Reactions of Peptidoglycan-Mimetic β-Lactams with Penicillin-Binding Proteins In Vivo and in Membranes

The membrane-bound bacterial DD-peptidases or penicillin-binding proteins catalyze the final transpeptidation reaction of bacterial cell wall biosynthesis and are the targets of β-lactam antibiotics. Rather surprisingly, the substrate specificity of these enzymes is not well understood. In this pape...

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Detalhes bibliográficos
Main Authors: Kumar, Ish, Josephine, Helen R., Pratt, R.F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536641/
https://ncbi.nlm.nih.gov/pubmed/17894439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb7001347
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