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One-Flask Synthesis of Dinucleoside Tetra- and Pentaphosphates

[Image: see text] We report a one-flask route for synthesis of dinucleoside tetra and pentaphosphates, in isolated yields of 50 to 85%. This route relies on a mixture of PIII and PV chemistries, using phosphitylation of a protected nucleoside with 2-chloro-4H-l,3,2-benzo-dioxaphosphorin-4-one (salic...

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Autors principals: Han, Qianwei, Gaffney, Barbara L., Jones, Roger A.
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2535934/
https://ncbi.nlm.nih.gov/pubmed/16671785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol060491d
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