Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR-γ Agonist

Drug binding to plasma proteins restricts their free and active concentrations, thereby affecting their pharmacokinetic properties. Species differences in plasma protein levels complicate the understanding of interspecies pharmacodynamic and toxicological effects. MBX-102 acid/JNJ39659100 is a novel...

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Detalhes bibliográficos
Main Authors: Clarke, Holly J., Gregoire, Francine, Ma, Fang, Martin, Robert, Zhao, Spring, Lavan, Brian E.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2535826/
https://ncbi.nlm.nih.gov/pubmed/18815616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/465715
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