Discontinuous transcription generates heterogeneity at the leader fusion sites of coronavirus mRNAs.

Coronavirus mRNA is synthesized by a discontinuous transcription process, which involves a free leader RNA species. As a result, each virus-specific mRNA contains an identical leader RNA derived from the 5', end of the genomic RNA. In this study, we demonstrate by primer extension studies that...

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Bibliographic Details
Published in:J Virol
Main Authors: Makino, S, Soe, L H, Shieh, C K, Lai, M M
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1988
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC253535/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2843681/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.62.10.3870-3873.1988
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