Topoisomerase I is preferentially associated with isolated replicating simian virus 40 molecules after treatment of infected cells with camptothecin.

Detergent extraction of simian virus 40 (SV40) DNA from infected monkey CV-1 cells, after a brief exposure to the drug camptothecin, yields covalent complexes between topoisomerase I and DNA that band with reduced buoyant densities in CsCl. The following lines of evidence indicate that the enzyme is...

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Pubblicato in:	J Virol
Autore principale:	Champoux, J J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC253510/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2843668/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.62.10.3675-3683.1988
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