Genetic evidence that the avian retrovirus DNA endonuclease domain of pol is necessary for viral integration.

We used in vitro mutagenesis in the 3' region of the avian retrovirus polymerase (pol) gene to genetically define the role of the DNA endonuclease domain. In-frame insertional mutations, which were dispersed throughout the 5' region of pp32, produced a series of five replication-deficient mutants. I...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Quinn, T P, Grandgenett, D P
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC253383/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2836614/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.62.7.2307-2312.1988
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