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Collagen Fibril Formation: A NEW TARGET TO LIMIT FIBROSIS

We present a concept for reducing formation of fibrotic deposits by inhibiting self-assembly of collagen molecules into fibrils, a main component of fibrotic lesions. Employing monoclonal antibodies that bind to the telopeptide region of a collagen molecule, we found that blocking telopeptide-mediat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chung, Hye Jin, Steplewski, Andrzej, Chung, Kee Yang, Uitto, Jouni, Fertala, Andrzej
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533774/
https://ncbi.nlm.nih.gov/pubmed/18650436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804272200
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