Potentiometric and Relaxometric Properties of a Gadolinium-based MRI Contrast Agent for Sensing Tissue pH

The pH sensitive contrast agent, GdDOTA-4AmP (Gd1) has been successfully used to map tissue pH by MRI. Further studies now demonstrate that two distinct chemical forms of the complex can be prepared depending upon the pH at which Gd(3+) is mixed with ligand 1. The desired pH sensitive form of this c...

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Main Authors: Kálmán, Ferenc K., Woods, Mark, Caravan, Peter, Jurek, Paul, Spiller, Marga, Tircsó, Gyula, Király, Róbert, Brücher, Ernő, Sherry, A. Dean
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533746/
https://ncbi.nlm.nih.gov/pubmed/17539632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ic0702926
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