Structural basis for the catalytic mechanism of human phosphodiesterase 9

The phosphodiesterases (PDEs) are metal ion-dependent enzymes that regulate cellular signaling by metabolic inactivation of the ubiquitous second messengers cAMP and cGMP. In this role, the PDEs are involved in many biological and metabolic processes and are proven targets of successful drugs for th...

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Detalhes bibliográficos
Main Authors: Liu, Shenping, Mansour, Mahmoud N., Dillman, Keith S., Perez, Jose R., Danley, Dennis E., Aeed, Paul A., Simons, Samuel P., LeMotte, Peter K., Menniti, Frank S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533186/
https://ncbi.nlm.nih.gov/pubmed/18757755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708850105
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