Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1

Vascular endothelial growth factor (VEGF) acts as a hierarchically high switch of the angiogenic cascade by interacting with its high affinity VEGF receptors and with neuropilin co-receptors. VEGF(165) binds to both Neuropilin-1 (NP-1) and VEGFR-2, and it is believed that ligand binding forms an ext...

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Detalhes bibliográficos
Main Authors: Prahst, Claudia, Héroult, Mélanie, Lanahan, Anthony A., Uziel, Noa, Kessler, Ofra, Shraga-Heled, Niva, Simons, Michael, Neufeld, Gera, Augustin, Hellmut G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Accelerated Publication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533068/
https://ncbi.nlm.nih.gov/pubmed/18628209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C800137200
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