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Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA

Mitochondria form a highly dynamic tubular network, the morphology of which is regulated by frequent fission and fusion events. However, the role of mitochondrial fission in homeostasis of the organelle is still unknown. Here we report that preventing mitochondrial fission, by down-regulating expres...

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Detalhes bibliográficos
Main Authors: Parone, Philippe A., Da Cruz, Sandrine, Tondera, Daniel, Mattenberger, Yves, James, Dominic I., Maechler, Pierre, Barja, François, Martinou, Jean-Claude
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532749/
https://ncbi.nlm.nih.gov/pubmed/18806874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003257
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