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The Prion Protein is a Combined Zinc and Copper Binding Protein: Zn(2+) Alters the Distribution of Cu(2+) Coordination Modes
PrP binds copper in the highly conserved, unstructured N-terminal half of the protein. The octarepeat region consists of 4 tandem repeats of PHGGGWGQ and binds four equivalents of copper at full occupancy. Adjacent to the octarepeats are two additional histidines that may also bind copper. We recent...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2532507/ https://ncbi.nlm.nih.gov/pubmed/18034490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja077146j |
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