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Probing Ligand Binding to Duplex DNA using KMnO(4) Reactions and Electrospray Ionization Tandem Mass spectrometry
An ESI-MS/MS strategy employing the thymine-selective KMnO(4) oxidation reaction to detect conformational changes and ligand binding sites in non-covalent DNA/drug complexes is reported. ESI-MS/MS is used to detect specific mass shifts of the DNA ions that are associated with the oxidation of thymin...
Gorde:
| Egile Nagusiak: | , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2007
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2531255/ https://ncbi.nlm.nih.gov/pubmed/17508717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac070145p |
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