Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy

BACKGROUND: The membrane transporters such as P-glycoprotein (Pgp), the MDR1 gene product, are one of causes of treatment failure in cancer patients. In this study, the epigenetic mechanisms involved in differential MDR1 mRNA expression were compared between 10 gastric and 9 colon cancer cell lines....

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Main Authors: Lee, Tae-Bum, Park, Jung-Hee, Min, Young-Don, Kim, Kyung-Jong, Choi, Cheol-Hee
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529328/
https://ncbi.nlm.nih.gov/pubmed/18673531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-230X-8-33
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