Restricted replication of mouse hepatitis virus A59 in primary mouse brain astrocytes correlates with reduced pathogenicity.

Temperature-sensitive (ts) mutants of mouse hepatitis virus A59 (MHV-A59) are drastically attenuated in their pathogenic properties. Intracerebral inoculation of mice with 10(5) PFU of mutant ts342 results in prolonged infection of the central nervous system, whereas 100 PFU of wild-type virus are l...

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Dettagli Bibliografici
Autori principali: van Berlo, M F, Wolswijk, G, Calafat, J, Koolen, M J, Horzinek, M C, van der Zeijst, B A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1986
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC252928/
https://ncbi.nlm.nih.gov/pubmed/3009857
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