Inadequate Activation of the GTPase RhoA Contributes to the Lack of Fibronectin Matrix Assembly in von Hippel-Lindau Protein-defective Renal Cancer Cells

The von Hippel-Lindau (VHL) tumor suppressor gene regulates extracellular matrix deposition. In VHL negative renal cancer cells, VHL(-), the lack of fibronectin matrix assembly is thought to promote and maintain tumor angiogenesis allowing vessels to infiltrate tumors. Therefore, and considering the...

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Autori principali: Feijóo-Cuaresma, Monica, Méndez, Fernando, Maqueda, Alfredo, Esteban, Miguel A., Naranjo-Suarez, Salvador, Castellanos, Maria C., del Cerro, Mercedes Hernández, Vazquez, Silvia N., García-Pardo, Angeles, Landázuri, Manuel O., Calzada, Maria J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Mechanisms of Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529126/
https://ncbi.nlm.nih.gov/pubmed/18567581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709390200
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