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Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing
During the clonal expansion of cancer from an ancestral cell with an initiating oncogenic mutation to symptomatic neoplasm, the occurrence of somatic mutations (both driver and passenger) can be used to track the on-going evolution of the neoplasm. All subclones within a cancer are phylogenetically...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2529122/ https://ncbi.nlm.nih.gov/pubmed/18723673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801523105 |
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