Vasopressin-stimulated Increase in Phosphorylation at Ser(269) Potentiates Plasma Membrane Retention of Aquaporin-2

Vasopressin controls water excretion through regulation of aquaporin-2 (AQP2) trafficking in renal collecting duct cells. Using mass spectrometry, we previously demonstrated four phosphorylated serines (Ser(256), Ser(261), Ser(264), and Ser(269)) in the carboxyl-terminal tail of rat AQP2. Here, we u...

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Autori principali: Hoffert, Jason D., Fenton, Robert A., Moeller, Hanne B., Simons, Brigitte, Tchapyjnikov, Dmitry, McDill, Bradley W., Yu, Ming-Jiun, Pisitkun, Trairak, Chen, Feng, Knepper, Mark A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Membrane Transport, Structure, Function, and Biogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528999/
https://ncbi.nlm.nih.gov/pubmed/18606813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803074200
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