Genetic Separation of FK506 Susceptibility and Drug Transport in the Yeast Pdr5 ATP-binding Cassette Multidrug Resistance Transporter

Overexpression of the yeast Pdr5 ATP-binding cassette transporter leads to pleiotropic drug resistance to a variety of structurally unrelated cytotoxic compounds. To identify Pdr5 residues involved in substrate recognition and/or drug transport, we used a combination of random in vitro mutagenesis a...

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Bibliographic Details
Main Authors: Egner, Ralf, Rosenthal, Friederike E., Kralli, Anastasia, Sanglard, Dominique, Kuchler, Karl
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 1998
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC25282/
https://ncbi.nlm.nih.gov/pubmed/9450972
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