Genetic Separation of FK506 Susceptibility and Drug Transport in the Yeast Pdr5 ATP-binding Cassette Multidrug Resistance Transporter

Overexpression of the yeast Pdr5 ATP-binding cassette transporter leads to pleiotropic drug resistance to a variety of structurally unrelated cytotoxic compounds. To identify Pdr5 residues involved in substrate recognition and/or drug transport, we used a combination of random in vitro mutagenesis a...

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Bibliographic Details

Published in:	Mol Biol Cell
Main Authors:	Egner, Ralf, Rosenthal, Friederike E., Kralli, Anastasia, Sanglard, Dominique, Kuchler, Karl
Format:	Artigo
Language:	Inglês
Published:	American Society for Cell Biology 1998
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25282/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9450972/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.9.2.523
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