Displayed correlation between gene expression profiles and submicroscopic alterations in response to cetuximab, gefitinib and EGF in human colon cancer cell lines

BACKGROUND: EGFR is frequently overexpressed in colon cancer. We characterized HT-29 and Caco-2, human colon cancer cell lines, untreated and treated with cetuximab or gefitinib alone and in combination with EGF. METHODS: Cell growth was determined using a variation on the MTT assay. Cell-cycle anal...

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Huvudupphovsmän: Solmi, Rossella, Lauriola, Mattia, Francesconi, Mirko, Martini, Désirée, Voltattorni, Manuela, Ceccarelli, Claudio, Ugolini, Giampaolo, Rosati, Giancarlo, Zanotti, Simone, Montroni, Isacco, Mattei, Gabriella, Taffurelli, Mario, Santini, Donatella, Pezzetti, Furio, Ruggeri, Alessandro, Castellani, Gastone, Guidotti, Lia, Coppola, Domenico, Strippoli, Pierluigi
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2008
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528013/
https://ncbi.nlm.nih.gov/pubmed/18691415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-227
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