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Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn(2+) and NR1 antagonist

Coassembly of the glycine-binding NMDA receptor subunits NR1 and NR3A results in excitatory glycine receptors of low efficacy. Here, we report that micromolar concentrations of the divalent cation Zn(2+) produce a 10-fold potentiation of NR1/NR3A receptor responses, which resembles that seen upon an...

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Autors principals: Madry, Christian, Betz, Heinrich, Geiger, Jörg R. P., Laube, Bodo
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527951/
https://ncbi.nlm.nih.gov/pubmed/18711142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805624105
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