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Consanguineous marriages and endemic malaria: can inbreeding increase population fitness?

BACKGROUND: The practice of consanguineous marriages is widespread in countries with endemic malaria. In these regions, consanguinity increases the prevalence of α(+)-thalassemia, which is protective against malaria. However, it also causes an excessive mortality amongst the offspring due to an incr...

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Autors principals: Denic, Srdjan, Nagelkerke, Nicolas, Agarwal, Mukesh M
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527611/
https://ncbi.nlm.nih.gov/pubmed/18673576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-7-150
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