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Targeting FtsZ for anti-tuberculosis drug discovery: non-cytotoxic taxanes as novel anti-tuberculosis agents
Screening of 120 taxanes identified a number of compounds that exhibited significant anti-tuberculosis activity. Rational optimization of selected compounds led to the discovery that the C-seco-taxane-multidrug-resistance (MDR) reversal agents (C-seco-TRAs) are non-cytotoxic at the upper limit of so...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527599/ https://ncbi.nlm.nih.gov/pubmed/16420032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050920y |
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